A review of MRI studies of progressive brain changes in schizophrenia.
نویسندگان
چکیده
In the early twentieth century, when Kraepelin first described ‘dementia praecox’ which eventually evolved into the concept of schizophrenia, he proposed that dementia praecox was probably an unknown organic brain disease. However, in contrast to the case of Alzheimer’s disease and Huntington’s disease, subsequent pathological studies of the brain failed to establish the neuropathology of schizophrenia. As a result, it had been generally accepted that schizophrenia would be a functional psychosis with neurochemical aberrations but without organic abnormalities. In 1976, Johnstone et al first reported the computerassisted tomography (CT) finding of lateral ventricular enlargement in patients with schizophrenia. This finding has been replicated in a number of CT studies and has been recognized as representing brain structural abnormalities in schizophrenia. Magnetic resonance imaging (MRI) enables more detailed and quantitative assessments of the fine brain structures, providing considerable evidence for the view that schizophrenia is a brain disorder with structural brain abnormalities.
منابع مشابه
Brain Structural Effects of Antipsychotic Treatment in Schizophrenia: A Systematic Review.
The findings about the progressive brain changes in schizophrenia are controversial, and the potential confounding effect of antipsychotics on brain structure is still under debate. The goal of the current article was to review the existing longitudinal neuroimaging studies addressing the impact of antipsychotic drug treatment on brain changes in schizophrenia. A comprehensive search of PubMed ...
متن کاملProgressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies
CONTEXT Antipsychotic treatment is the first-line treatment option for schizophrenia. Individual studies suggested they can significantly affect brain structure and account for progressive brain changes observed during the illness. OBJECTIVES To quantitatively examine the effect of antipsychotics as compared to illness related factors on progressive brain changes in schizophrenia. DATA SOUR...
متن کاملSuperior temporal gyrus volume change in schizophrenia: a review on region of interest volumetric studies.
Imaging studies of schizophrenia (SCZ) have repeatedly demonstrated volume differences in superior temporal gyrus (STG) and its subregions. Among them, some studies employed the Region of Interest (ROI) method. We carried out a systematic review of the published literature on STG volumetry MRI studies to examine the potential of ROI method for identifying specific structural differences and cor...
متن کاملBrain Single Photon Emission Computed Tomography Scan (SPECT) and Functional MRI in Systemic Lupus Erythematosus Patients with Cognitive Dysfunction: A Systematic Review
Objective(s): Systemic lupus erythematosus (SLE) is an autoimmune disease with a wide range of clinical manifestations. Cognitive dysfunction is one of the manifestations that could present prior to the emergence of any other neuropsychiatric involvements in SLE. Cognitive dysfunction is a subtle condition occurring with ahigh frequency. However, there is no data on the correlation of cognitive...
متن کاملWhat happens after the first episode? A review of progressive brain changes in chronically ill patients with schizophrenia.
Numerous imaging studies have revealed structural brain changes in schizophrenia. Decreases in brain tissue are accompanied by increases in ventricle volumes and cerebrospinal fluid. Whether or not these brain changes are progressive beyond the first episode is subject to debate. To assess if progressive brain changes occur in chronically ill patients, 11 longitudinal magnetic resonance imaging...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of medical and dental sciences
دوره 48 3 شماره
صفحات -
تاریخ انتشار 2001